Real-time Monitoring of Motor Cortical Activity Induced by Low-frequency Repetitive Transcranial Magnetic Stimulation

N/ACompletedNCT04019028

Samsung Medical Center10 enrolled

Overview

In this study, we investigated the effect of low-frequency repetitive trans cranial magnetic stimulation, one of the noninvasive brain stimuli, on the functional changes of the bilateral motor cortical activity in normal subjects using functional near infrared spectroscopy (fNIRS).

In normal subjects, 1. the effect of low-frequency repetitive transcranial magnetic stimulation on cerebral cortex are measured in real time using fNIRS. 2. Changes in cerebral cortical activity before and after stimulation are measured using the motor function test and the motor-induced potential test

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

OTHER

Masking

SINGLE

Enrollment

Conditions

Healthy

Interventions

low frequency rTMS + Navigation SystemDEVICE

1Hz low-frequency rTMS stimulation over primary motor area using navigation system

only low frequency rTMSDEVICE

1Hz low-frequency rTMS stimulation over primary motor area

Sham low frequency rTMS + Navigation SystemDEVICE

1Hz low-frequency sham rTMS stimulation over primary motor area using navigation system

Eligibility

Sex: ALLMin age: 19 YearsMax age: 69 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Healthy adult men and women without history of central nervous system disease and abnormalities Exclusion Criteria: * Under 18 years old, 70 years old or older * A person who has inserted a metal object in a skull * A person with complete occlusion of the carotid artery * A person with epilepsy * Pregnant and lactating women * Who is not eligible for the test

Locations (1)

Samsung Medical Center

Seoul, South Korea

Outcomes

Primary Outcomes

Changes of Cortical activation

Cortical activation is measured by functional Near-Infrared-Spectroscopy (fNIRS) (NIRScout, NIRx, Germany) before and after stimulation

Time frame: Baseline and after intervention[Immediately after 20 minutes of intervention]

Secondary Outcomes

Changes in motor evoked potentia

measure the motor threshold and amplitude of motor evoked potential in first dorsal interosseous muscle.

Time frame: Baseline and after intervention[Immediately after 20 minutes of intervention]

changes in nine hole peg test

Nine-Hole Peg Test is used to measure finger dexterity in patients with various neurological diagnoses.

Time frame: Baseline and after intervention[Immediately after 20 minutes of intervention]

Sequential motor task

It is a training exercise in which five digits are repeatedly pressed with five fingers using individual movements, and it is trained to press the button accurately and quickly.

Time frame: Baseline and after intervention[Immediately after 20 minutes of intervention]

Data from ClinicalTrials.gov

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