Cereals and Intestinal Function

N/ACompletedNCT04019457

University of Vienna17 enrolled

Overview

The aim of the present study is to determine the effect of dietary fiber on intestinal function in healthy subjects.

In the intervention study normal weight participants will receive defined amounts of different cereal flakes for several days. Before and after intervention parameters of intestinal function will be assessed.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

SINGLE

Enrollment

Conditions

Endotoxemia Diet, Healthy

Interventions

Dietary interventionOTHER

Dietary intervention: Participants receive dietary fibers for a defined number of days.

Eligibility

Sex: ALLMin age: 20 YearsMax age: 60 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * BMI \<25 kg/m2 * daily alcohol consumption \<20g (men) or \<10g (women) Exclusion Criteria: * food allergies or intolerances * instable body weight * BMI \<18,5 kg/m2 or \>25 kg/m2 * bariatric surgery within the last 5 years * intake of antibiotics within the last month or during the study * daily alcohol consumption \>20g (men) or \>10g (women) * pregnancy and/or lactation period * viral or bacterial infection during the last three weeks * increased inflammatory markers of unknown reason * chronic or acute disease of gastrointestinal tract

Locations (1)

University of Vienna

Vienna, Austria

Outcomes

Primary Outcomes

Changes in parameters of intestinal barrier function

Changes in endotoxin plasma levels

Time frame: 1 week

Secondary Outcomes

Changes in blood lipid levels

Changes in triglyceride levels (mg/dl), changes in cholesterol levels (mg/dl)

Time frame: 1 week

Data from ClinicalTrials.gov

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