This study aims to improve the pathophysiological understanding of migraine in in a longitudinal observational study investigating changes of established neurophysiological and imaging parameters in line with changes of the clinical phenotype. The study's focus is the investigation of mechanisms that are directly related to the cyclic character of migraine and its core structures. In this context, the primary endpoint is a change in the nociceptive blink reflex, an established brain stem reflex to study the trigemino-spinal system, associated with changes in migraine frequency and severity. In order to reliably detect changes in the trigeminal pain system, investigations are performed in patients before starting a prophylactic therapy and 3 months afterwards. Several secondary endpoints are used to evaluate changes of multimodal sensory and cortical information processing. Cerebral imaging will include examinations of structural and network effects of altered migraine disease activity.
Study Type
OBSERVATIONAL
Enrollment
44
the study is observational and does not interfere with clinical routine. In lin with this notion, the intervention is chosen by the treating physician in a shared decision making process involving the patient
Department of Neurology
Greifswald, Mecklenburg-Vorpommern, Germany
nociceptive blink reflex habituation
habituation of the area under of the curve of the R2 blink reflex component on the side primarily affected by migraine headaches
Time frame: baseline and after 3 months
nociceptive blink reflex area
area under of the curve of the R2 blink reflex component on the side primarily affected by migraine headaches
Time frame: baseline and after 3 months
somatosensory evoked potentials (SSEP)
habituation of the N20 SSEP component following bilateral median nerve stimulation
Time frame: baseline and after 3 months
pattern-reversal visual evoked potentials (VEP)
habituation of the P100 VEP component following bilateral optic nerve stimulation
Time frame: baseline and after 3 months
migraine headache frequency
days with migraine headaches during the last month
Time frame: baseline and after 3 months
headache impact test (HIT-6)
impact of migraine severity on daily routine
Time frame: baseline and after 3 months
migraine disability assessment (MIDAS)
impact of migraine frequency on daily routine
Time frame: baseline and after 3 months
Patient-Reported Outcomes Measurement Information System Profile 29 (PROMIS-29)
multi domain patient reported quality of life
Time frame: baseline and after 3 months
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