Urinary kallidinogenase may assist recovery acute ischemic stroke. This study evaluated the impact of urinary kallidinogenase on NIHSS score, modified Rankin scale (mRS) score and fasting glucose levels in patients with AIS combined with diabetes mellitus and impaired fasting glucose.
Patients with AIS and abnormal glucose metabolism were enrolled in this prospective cohort study and divided into two groups. The HUK group were treated with urinary kallidinogenase and standard treatment, the control group received standard treatment. NIHSS scores, mRS scores and fasting blood glucose were evaluated and compared.
Study Type
OBSERVATIONAL
Enrollment
113
NIHSS Score at 90 Days
Comparison of NIHSS score between the control and HUK group at 90 days
Time frame: at 90 days after admission
NIHSS Score at 10 Days、30 Days
Comparison of NIHSS score between the control and HUK group at 10days、30days.
Time frame: at 10 days, 30 days after admission
Factors related to Non-General Recovery (90-day NIHSS was reduced by <90%)
Based on NIHSS score,multivariate analysis was performed to evaluate the factors related to non-general recovery (90-day NIHSS was reduced by \<90%) for all patients. Evaluation of NIHSS score: General recovery was when NIHSS score was reduced by 90%-100%; Non-general recovery referred to when NIHSS score was reduced by \<90%.
Time frame: at 90 days after admission
mRS Score
The mRS score of 10 days after admission was taken as the baseline.Comparison of mRS score between the control and HUK group at 30days、90days. Based on mRS,multivariate analysis was also performed to evaluate the factors related to poor curative effect (90-day mRS ≥3) for all patients. Evaluation of mRS score: mRS score of 0-2 points referred to a good curative effect, and 3-5 points referred to a poor curative effect.
Time frame: 10 days, 30 days, and 90 days after admission
fasting glucose levels
Comparison of the change in fasting glucose levels between the control and HUK group at admission and 10days.
Time frame: at admission and 10 days after admission
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