Myeloid-Derived Suppressor Cell Function in Breast Cancer Patients

N/ARecruitingNCT04022616

Ohio State University Comprehensive Cancer Center99 enrolled

Overview

Study Type

OBSERVATIONAL

Enrollment

Conditions

Breast Cancer

Interventions

Specimen collectionOTHER

Specimens are obtained from patients who are being treated for breast malignancies.

Eligibility

Sex: FEMALEMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * 18 years of age or older * Ability to give informed consent * Stage I-III breast malignancy Exclusion Criteria: * Unable to tolerate venipuncture

Locations (1)

Ohio State University Comprehensive Cancer Center

Columbus, Ohio, United States

RECRUITING

Outcomes

Primary Outcomes

Isolate unfavorable immune cells MDSC from the peripheral blood or tumors of study subjects and test how strongly they inhibit function of favorable immune cells called Natural Killer Cells.

Function of Natural Killer Cells will be studied by measuring their ability to kill target cancer cells coated with monoclonal antibodies. isolate unfavorable immune cells called Myeloid Derived Suppressor Cells (MDSC) from the peripheral blood or the tumors of study subjects and test how strongly they inhibit function of favorable immune cells called Natural Killer Cells. Function of Natural Killer Cells will be studied by measuring their ability to kill target cancer cells coated with monoclonal antibodies.

Time frame: up to 1 year

Secondary Outcomes

Isolate unfavorable immune cells called Myeloid Derived Suppressor Cells (MDSC) from the peripheral blood of study subjects who plan to start pre-operative chemotherapy for breast cancer to see if MDSC levels can predict who will respond to treatment. W

Percentage of MDSC at baseline and whether there is an association of baseline MDSC percent with response to chemotherapy.

Time frame: up to 1 year

Isolate unfavorable immune cells MDSC from peripheral blood of study subjects who receive pre-operative chemotherapy for breast cancer to identify changes in MDSC levels during treatment can predict who will respond to treatment.

Changes will be reported in percentage of MDSC and associations of such changes with response to chemotherapy.

Time frame: up to 1 year

Isolate lymph nodes from patients with breast cancer undergoing breast surgery to study what types of Natural Killer Cells are present.

Isolate a lymph nodes from patients with breast cancer undergoing breast surgery to study what types of Natural Killer Cells are present. Natural Killer cells are immune cells that are capable of killing cancer cells.

Time frame: up to 1 year

Central Contacts

Ohio State Comprehensive Cancer Center

CONTACT

1-800-293-5066 OSUCCCClinicaltrials@osumc.edu

Data from ClinicalTrials.gov

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