Remifentanil in Deep vs Moderate Neuromuscular Blocks During Surgical Pleth Index-guided Anesthesia for Laparoscopic Herniorrhaphy

Ajou University School of Medicine134 enrolled

Overview

The primary purpose of this study is to compare the remifentanil requirements in deep versus moderate neuromuscular blocks during the surgical pleth index -guided anesthesia in patients undergoing laparoscopic herniorrhaphy.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

QUADRUPLE

Enrollment

134

Conditions

Hernia Abdominal Wall

Interventions

Moderate neuromuscular blockDRUG

maintaining of moderate neuromuscular block (train-of-four count 1-2) during surgery, reversal using neostigmine 50 ug/kg and glycopyrrolate 10 ug/kg

Deep neuromuscular blockDRUG

maintaining of deep neuromuscular block (posttetanic count 1-2) during surgery, reversal using sugammadex 4 mg/kg based on actual body weight

Eligibility

Sex: ALLMin age: 19 YearsMax age: 85 Years

Medical Language ↔ Plain English

Inclusion Criteria: * laparoscopic hernia repair Exclusion Criteria: * patients refusal, hyperbilirubinemia, chronic pain, opioid abuse, infection, and peripheral disease

Locations (1)

Department of Anesthesiology and Pain Medicine, Ajou University School of Medicine

Suwon, Gyeonggido, South Korea

Outcomes

Primary Outcomes

Remifentanil Infusion Rate

remifentanil infusion using target effect-site concentration to achieve an surgical pleth index of range between 25 and 50

Time frame: from pneumoperitoneum to removal of laparoscope, an average of 30 minutes

Data from ClinicalTrials.gov

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