The objective of the study is to evaluate at birth, the diversity of the T repertoire of newborns exposed in utero to anti-integrases in comparison with a control group of children exposed to other antiretroviral drugs.
Antiretroviral treatment during pregnancy is remarkably effective in preventing the transmission of mother-to-child viruses. Molecules of the class of anti-integrases are still little used during pregnancy, but their prescription is increasing given their intrinsic effectiveness and their overall tolerance profile. The integrase of HIV-1, responsible for the integration of viral DNA in cellular DNA, has a functional similarity with human RAG1 / 2 proteins, responsible for V (D) J recombination. RAG1 / 2 proteins alteration is associated in human clinic with immune disturbances of varied severity. The objective of the study is to evaluate at birth, the diversity of the T repertoire of newborns exposed in utero to anti-integrases in comparison with a control group of children exposed to other antiretroviral drugs.
Study Type
OBSERVATIONAL
Enrollment
29
Single blood sample of 2 ml at birth on the occasion of blood sampling routine checkup
AP-HP, Hôpital Louis Mourier
Colombes, France
AP-HP, Hôpital de la Pitié Salpêtrière
Paris, France
AP-HP, Hôpital Cochin
Paris, France
AP-HP, Hôpital Necker
Paris, France
AP-HP, Hôpital Bichat-Claude Bernard
Newborn immunity
T cells immune repertoire integrity
Time frame: 18 months
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Paris, France