The investigators will collect blood samples of different courses of VKH patients for investigating immune profile, observe major immune cells number ,functional and membrane molecular changes in the course of treatment, to investigate pathogenesis of VKH. Meanwhile, the investigators will collect clinical data of VKH patients to observe choroid and retina change in different courses.
Study Type
OBSERVATIONAL
Enrollment
48
IV and oral steroids
Wuhan Aier eye hospital
Wuhan, Hubei, China
RECRUITINGT/B /NK(natural killer )/monocyte...etc, cell numbers of blood samples in VKH patients
use flow cytometry to count T/B /NK/monocyte...etc, cell numbers
Time frame: one year
T/B /NK/monocyte...etc cell subtype proportion in blood samples in VKH patients
use flow cytometry to measure T/B /NK/monocyte...etc cell subtype proportion
Time frame: one year
T/B /NK/monocyte...etc cell functional change in VKH patients
use ELISA(enzyme linked immunosorbent assay) to measure inflammatory cytokines level in peripheral blood
Time frame: one year
choroid and retinal thickness change in different course of VKH patients
Use OCT（optical coherence tomography） to measure choroid and retina thickness changes in macular zone of different course VKH patients
Time frame: one year
Use OCTA(optical coherence tomography angiography) to measure macular and optic disc vascular index
Use OCTA to measure macular and optic disc vascular index in different course VKH patients
Time frame: one year
Use Maia perimeter to measure macular integrality
Use Maia perimeter to measure macular integrality including light threshold and central fixation.
Time frame: one year
measure the Injury degree of choroid and retinal vessels
Use FFA(fluorescein fundus angiography)/ICG(Indocyanine Green Angiography) to measure the Injury degree of choroid and retinal vessels
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Time frame: one year