To provide comprehensive efficacy and safety profiles of neoadjuvant chemoradiotherapy (NCRT) versus neoadjuvant chemotherapy (NCT) versus surgery alone in resectable oesophageal carcinoma.
Neoadjuvant chemotherapy (NCT) or neoadjuvant chemoradiotherapy (NCRT) has been shown to be better than surgery alone in patients with resectable oesophageal carcinoma, but higher quality evidence is needed as new findings have emerged regarding this issue.Previous evidence-based findings and the current guidelines have not established a survival advantage of NCRT over NCT or an acceptable safety profile of the addition of radiotherapy to NCT; whether NCRT or NCT is more effective for the treatment of adenocarcinoma or squamous cell carcinoma of the oesophagus is unclear.This study aims to provide comprehensive efficacy and safety profiles of NCRT versus NCT versus surgery alone in resectable oesophageal carcinoma.
Study Type
OBSERVATIONAL
Enrollment
423
In most patients, the chemotherapy regimens before surgery were consisted of cisplatin combined with either fluorouracil or taxanes.
Various surgical oesophagectomy methods were used, such as Ivor Lewis, transthoracic, three-hole, transhiatal, and left transthoracic,and the appropriate surgical approach for each patient was chosen according to the tumour location, size, and depth.
In most patients, the chemotherapy regimens before surgery were consisted of cisplatin combined with either fluorouracil or taxanes.
Massachusetts General Hospital of Harvard Medical School
Boston, Massachusetts, United States
Guangdong Provincial People's Hospital
Guangzhou, Guangdong, China
Sun Yat-Sen Memorial Hospital of Sun Yat-sen University
Guangzhou, Guangdong, China
Overall survival (OS)
The OS was calculated as the time from the date of the histologically documented diagnosis to the date of death or the final follow-up.
Time frame: 5 years
Disease-free survival (DFS)
DFS was calculated from the date of R0 resection to the date of disease recurrence or death from any cause
Time frame: 5 years
R0 resection rate
R0 resection was defined as gross disease removed with negative margins (tumour-free resection margin).
Time frame: Baseline
Pathologic complete response (pCR)
pCR was defined as no evidence of residual tumour cells in the primary site and resected lymph nodes of the operative specimens.
Time frame: Baseline
30-day postoperative or in-hospital mortality
Time frame: 30 days
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