Safety and Effectiveness of Remote Ischemic Conditioning Combined With Intravenous Thrombolysis in Treating Acute Ischemic Stroke

Inclusion Criteria: * 1\) Age≥18 years, \< 80 years, regardless of sex; * 2\) Patients with clinically definite diagnosis of acute ischemic stroke and undergo intravenous thrombolysis; * 3\) Baseline NIHSS \>= 5, and \<= 25; * 4\) Baseline GCS ≥8; * 5\) Signed and dated informed consent is obtained Exclusion Criteria: * 1\) Patients who undergo endovascular treatment; * 2\) mRS ≥ 2 before the onset of the disease; * 3\) Double upper limbs or lower limbs paralysis was found in this case; * 4\) Active bleeding of organs within 6 months of admission or current, including cerebral hemorrhage, subarachnoid hemorrhage, gastrointestinal hemorrhage, fundus hemorrhage and so on; * 5\) Other intracranial lesions, such as cerebrovascular malformation cerebral venous diseases, tumor and other diseases involving the brain; * 6\) Concurrent use of anticoagulation drugs including Warfarin, dabigatran, rivaroxaban; * 7\) Severe organ dysfunction or failure; * 8\) Patients suffering from severe hematological diseases or severe coagulation disorder dysfunction * 9\) Those who have a history of severe trauma or had major surgery within 6 months prior to admission; * 10\) Those who have a history of atrial fibrillation; * 11\) The patients who have the contraindication of remote ischemic conditioning treatment, such as severe soft tissue injury, fracture or vascular injury in the upper limb#Acute or subacute venous thrombosis, arterial occlusive disease, subclavian steal syndrome, etc; * 12\) Pregnant or lactating women; * 13\) Previous remote ischemic conditioning therapy or similar treatment; * 14\) Patients with a life expectancy of less than 3 months or patients unable to complete the study for other reasons; * 15\) Severe hepatic and renal dysfunction; * 16\) Unwilling to be followed up or treated for poor compliance; * 17\) He/She is participating in other clinical research or has participated in other clinical research or has participated in this study within 3 months prior to admission; * 18\) Other conditions that the researchers think are not suitable for the group.