Pulmonary recruitment maneuvers open these lung areas and appropriate adjustment of positive expiratory pressure (PEP) helps to stabilize recruitment and reduce the stress associated with alveolar opening and closing. Its beneficial effects in the lung affected by Acute Respiratory Distress Syndrome (ARDS) remain unclear. The hypothesis is that there is a heterogeneous effect of the recruitment maneuver according to the phenotype of ARDS. It is important to be able to define responder patients from non-responders to this recruiting maneuver.
It will be a prospective interventional study in resuscitation patients with severe or moderate ARDS. This study will be multicentric between the University Hospital of Amiens and intensive care of Lens, intensive care of Bethune and intensive care of Arras. All patients in intensive care and severe, moderate ARDS will be included in this study. All patients will benefit from Lung ultrasound (LUS) with a mapping of each lung looking for normal or pathological lung profiles, as well as a measurement of esophageal pressure (Peso) at rest. A "PEP titration pulmonary opening" (PEP-OP) test using a recruitment maneuver was then performed in all patients followed by a new LUS and Peso measurement.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
OTHER
Masking
NONE
Enrollment
4
PEP titration pulmonary opening (PEP-OP) was performed in all patients followed by new LUS and Peso measurement.
Chu Amiens
Amiens, France
CH Arras
Arras, France
Ch Germon Et Gauthier
Béthune, France
Hospital Dr Schaffner
Lens, France
oxygenation and pulmonary compliance
The primary outcome is oxygenation (PaO2 / FiO2) and pulmonary compliance ((Pplat-Pep) / VT) at 1h of the PEP-OP test.
Time frame: at 1 hours of the PEP-OP test.
Oxygenation (PaO2 / FiO2) at 6h, 12h, 24h
Oxygenation (PaO2 / FiO2) at 6h, 12h, 24h
Time frame: at 6 hours, 12 hours, 24 hours of the PEP-OP test
Mechanical ventilation time
Mechanical ventilation time
Time frame: Discharge from intensive care unit
Hospitalization in intensive care time
Hospitalization in intensive care time
Time frame: Discharge from intensive care unit
The need for recourse to alternative therapies of oxygenation
The need for recourse to alternative therapies of oxygenation
Time frame: Discharge from intensive care unit
Incidence of barotrauma
Incidence of barotrauma
Time frame: After PEP-OP
Pulmonary compliance at 6 hours, 12 hours and 24 hours
Pulmonary compliance at 6 hours, 12 hours and 24 hours
Time frame: at 6 hours, 12 hours and 24 hours of the PEP-OP test.
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