The Study of Qishenyiqi Drop Pills in Improving the Prognosis of Heart Failure Patients

Inclusion Criteria: * Ability to understand the requirements of the study and willingness to provide written informed consent. * Male or female subjects aged ≥ 18 years * Patients with ejection fraction decreased heart failure (NYHA II-IV, Echocardiography with Simpson method within four weeks and NT-proBNP within two weeks before random) （1）35%≤LVEF≤40% ; NT-proBNP≥900pg/ml, patients with renal dysfunction (glomerular filtration rate \<60 ml/min/1.73m2）or atrial fibrillation, the NT-proBNP should be ≥1200 pg/ml； （2）LVEF\<35% (Simpson method); NT-proBNP≥600pg/ml, patients with renal dysfunction (glomerular filtration rate \<60 ml/min/1.73m2）or atrial fibrillation, the NT-proBNP should be ≥900 pg/ml. * A history of hospitalization or emergency treatment for heart failure in the past two years and a diagnosis of heart failure at least one month ago * The use of medications in line with the recommendation of China heart failure treatment guidelines for at least 4 weeks. (Please confirm that all the following conditions must be met) : Including a ACEI or ARB, and a beta- blocker, unless contraindicated or not tolerated. The doses should reach the target dose recommended by the guideline or the maximum dose that the patient can tolerate, and the doses should not be changed within one months prior to screening and randomization (patients not take such drugs according to the guidelines, should be recorded). Exclusion Criteria: * Acute decompensated HF with hemodynamic instability, mechanical hemodynamic support or invasive mechanical ventilation within 14 days of randomization, using intravenous positive inotropic drugs, vasoactive drugs and intravenous diuretics within 7 days before randomization. * Poorly controlled hypertension, defined as resting systolic blood pressure≥180mmHg and /or diastolic blood pressure ≥110mmHg assessed on two separate occasions prior to randomization. * Liver transaminase (ALT or AST), bilirubin more than 3 times the upper limit of normal not caused by heart failure, glomerular filtration rate\<15ml/min/1.73m2. * Hemoglobin concentration ≤ 9.0g/dl and/or have blood system disease. * Valvular heart disease, congenital heart disease without surgery. * Cardiac shock. * Hypertrophic obstructive cardiomyopathy, restrictive cardiomyopathy, other secondary and invasive cardiomyopathy. * Active myocarditis. * Constrictive pericarditis, other pericardial diseases. * Syncope within 3 months. * Symptomatic bradycardia or II or III degrees heart block without a pacemaker. * Ventricular arrhythmias affecting hemodynamics. * Cardiac resynchronization therapy implanted pacemaker (CRT-P) or cardiac resynchronization therapy defibrillators (CRT-D) within 6 months, or upgrade the existing conventional pacemaker or implantable implantable defibrillator (ICD) to the CRT device, or have the intention to implant similar devices. * Occurred within 3 months: acute coronary syndrome, stroke, transient ischemic attack; Heart, carotid artery or other large vascular surgery; Percutaneous coronary intervention (PCI) or carotid artery angioplasty, CABG or other cardiac surgery. * Major surgery within 6 months prior to randomization. * Has a history of heart transplantation or are waiting for transplants or using left ventricular assist device (LVAD) or have intention to heart transplant (waiting for transplants) or implant the VAD. * Severe chronic obstructive pulmonary disease, pulmonary heart disease, sever pulmonary vascular disease, pulmonary hypertension caused by autoimmune disease, any type of severe pulmonary hypertension. * History of major organ transplant (such as lung, liver, heart, bone marrow, kidney). * Patients with serious primary diseases of liver, kidney, hematopoietic system, nervous system, endocrine system, and patients with cancer or mental illness. * Life expectancy is less than 1 year. * Known allergy to any study drug. * Participants in other clinical studies within 1 month. * Patients who are taking Chinese medicine and proprietary Chinese medicine with similar ingredients of QSYQ. * Women who have developed pregnancy (pregnancy test positive) or during lactation; women of childbearing age have not taken adequate contraceptive measures. * According to the researchers, patients could not complete the study or fail to comply with the requirements of the study (due to management or other reasons).