The Study of the Antimicrobial Resistance of Helicobacter Pylori in Shandong Province

Shandong University1,800 enrolled

Overview

The antimicrobial resistance of helicobacter pylori in Shandong province was analyzed by helicobacter pylori antibiotic sensitivity test.And the map of antimicrobial resistance of helicobacter pylori was constructed to provide clinical guidance for selecting effective eradication program and improve the eradication rate.

The patients with positive H. pylori infection that was not eradicated by previous therapies will accept the gastroscopy. The mucosa of the lesser curvature of gastric antrum and the greater curvature of the stomach will progress helicobacter pylori antibiotic sensitivity test to detect the antimicrobial resistance of helicobacter pylori.The antimicrobial resistance of helicobacter pylori in Shandong province will be described by frequency and percentage.

Study Type

OBSERVATIONAL

Enrollment

1,800

Conditions

Helicobacter Pylori

Eligibility

Sex: ALLMin age: 18 YearsMax age: 70 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients, aged between 18 and 70 years old, with positive H. pylori infection that was not eradicated by previous therapies are included. The H. pylori infection is confirmed by the positive rapid urease test or 13C-breath test. Exclusion Criteria: * Patients with significant underlying disease including liver, cardiac, pulmonary, and renal diseases, neoplasia, coagulopathy and genetic diseases, history of gastric surgery, pregnancy, breast-feeding, active gastrointestinal bleeding, the use of PPI, NSAID or antibiotics during the 4 weeks prior to enrolment, and previous history of allergic reactions to any of the medications used in this protocol. Patients previously treated with H. pylori eradication regimens or those unwilling to participate in the study were also excluded.

Locations (1)

Qilu Hospital of Shandong University

Jinan, Shandong, China

RECRUITING

Outcomes

Primary Outcomes

Antimicrobial resistance rate

The antimicrobial resistance rate will be described by the frequency and percentage.

Time frame: 3years

Secondary Outcomes

The influence factors of the antimicrobial resistance rate

The chi-square test will be used to compare the influence factors of the antimicrobial resistance rate.

Time frame: 3years

Central Contacts

Xiuli Zuo, MD,PhD

CONTACT

15588818685 zuoxiuli@sina.com

Tian Ma, MD

CONTACT

18769781098 matian1002@163.com

Data from ClinicalTrials.gov

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