The objective of the study is to evaluate the ability of a combination of plant extracts (BSL\_EP025) to reduce the levels of LDL-cholesterol and oxidized LDL-cholesterol in individuals with LDL-cholesterol levels between 100 and 190 mg/dL.
There is a strong relationship between serum cholesterol levels and cardiovascular diseases, especially between coronary artery disease and LDL-cholesterol (LDL). LDL is the lipoprotein responsible for delivering cholesterol to cells. However, in recent years, special attention has been given to modified LDL, especially oxidized LDL, since it plays a very important role in the initiation and progression of the atheroma plaque. There are environmental and genetic factors that can influence the type and levels of blood lipoproteins. Among the modulable factors (environmental) it has been observed that some phytochemical compounds found in several plant extracts may reduce cardiovascular risk, due to their antioxidant and anti-inflammatory properties. The objective of the present study is to evaluate the possible effect of the intake of a combination of plant extracts (BSL\_EP025) on the levels of LDL-cholesterol and oxidized LDL-cholesterol in healthy individuals with LDL-cholesterol levels between 100 and 190 mg/dL.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
QUADRUPLE
Enrollment
40
Each participant will consume 2 capsules daily at lunch for 8 weeks.
Each participant will consume 2 capsules daily at lunch for 8 weeks.
Biosearch Life
Granada, Andalusia, Spain
LDL cholesterol
Levels of LDL cholesterol in plasma
Time frame: 8 weeks
Oxidized LDL cholesterol
Levels of oxidized LDL cholesterol in plasma
Time frame: 8 weeks
Total cholesterol
Levels of total cholesterol in plasma
Time frame: 8 weeks
HDL cholesterol
Levels of HDL cholesterol in plasma
Time frame: 8 weeks
Triglycerides
Levels of triglycerides in plasma
Time frame: 8 weeks
Glucose
Levels of glucose in plasma
Time frame: 8 weeks
Blood pressure
Systolic and diastolic blood pressure
Time frame: 8 weeks
Body mass index
Weight/height ratio
Time frame: 8 weeks
VCAM-1
Plasma levels of VCAM-1
Time frame: 8 weeks
ICAM-1
Plasma levels of ICAM-1
Time frame: 8 weeks
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Beta IL-1
Plasma levels of beta IL-1
Time frame: 8 weeks
IL-6
Plasma levels of IL-6
Time frame: 8 weeks
IL-10
Plasma levels of IL-10
Time frame: 8 weeks