This study evaluates Different effects of two anesthetic techniques on renal function during the perioperative period of cardiac surgery in children.
Acute kidney injury is one of the major complications after heart surgery, which increases the mortality of patients. Therefore, early prevention and detection of acute kidney injury is particularly important. In recent years, more and more studies have shown that both sevoflurane, an inhaled anesthetic widely used in clinical practice, and propofol, an intravenous anesthetic, have protective effects on kidneys. The aim of this study was to investigate the perioperative effects of two different anesthetic techniques on renal function for pediatric cardiac surgery.
Study Type
OBSERVATIONAL
Enrollment
60
sevoflurane was used to maintain anesthesia
propofol was used to maintain anesthesia
Children's Hospital of Fudan University
Shanghai, Shanghai Municipality, China
renal blood flow
Changes of blood flow information of renal artery was obtained before anesthesia induction, after anesthesia, at the end of operation and 24 hours after surgery, unit(cm/s)
Time frame: 2 days
neutrophil gelatinase-associated lipocalin , NGAL
Changes of blood NGAL were obtained before and 2 hours after surgery, unit(ng/ml)
Time frame: 2 days
creatinine
Changes of creatinine before and 3 days after acquisition, unit (mmol/L)
Time frame: 3 and 4 days
Mean arterial pressure
Mean arterial pressure synchronized with renal blood flow was recorded, unit (mmHg)
Time frame: 2 days
cardiopulmonary bypass (CPB) time
Cardiopulmonary bypass time was recorded, unit(minutes)
Time frame: 24 hours
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