The aim of the study was to examine the prophylactic role of repetitive transcranial magnetic stimulation (rTMS) on the frequency, and severity of migraine attacks in episodic migraineurs who failed medical treatment. A group received 5 rTMS sessions, delivered over one week. Each rTMS session consisted of a single train of 900 total pulses over 3 minutes duration given at 5-Hz frequency and 100% motor threshold intensity and the placebo group received rTMS with the same stimulation frequency at a fixed intensity of 50% of the machine output
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
DOUBLE
Enrollment
33
Each rTMS session consisted of a single train of 900 total pulses over 3 minutes duration.
Each rTMS session consisted of a single train of 900 total pulses over 3 minutes duration.
Migraine attack frequency
The primary outcome measure was defined as the reduction of number of migraine attacks by at least 50% after rTMS sessions.
Time frame: 2 months
Migraine days
Number of days that the migraine attack lasts in
Time frame: 2 months
Migraine attack severity
The intensity of pain that was assessed using the zero to ten Numeric Pain Rating Scale (NPRS)
Time frame: 2 months
Functional disability
Functional disability was measured using the HIT-6 score. Severe HIT-6 was defined as a score of 60 or more. A clinically significant change in the HIT-6 was defined as a change of five points or more.
Time frame: 2 months
Use of abortive pills
Number of pills used per month
Time frame: 2 months
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