Efficacy and Tolerability of a Phytotherapy Combination (Aqualibra) in Patients With Uncomplicated Cystitis

Inclusion Criteria: * Female outpatients aged 18-75 years * Diagnosis of acute lower uUTI occurring for the first time or acute relapse of chronic recurrent uUTI * Typical symptoms of cystitis (pollakisuria, dysuria and urgency) * Bacterial count of 10\*4 - 10\*6 colony forming units (CFU)/mL in midstream urine * Presence of \>20 leukocytes/µL of urine measured by dipstick test * No antibiotic treatment required according to the investigator * Women of childbearing potential were allowed to participate only if they used a highly effective method of contraception * Written informed consent Exclusion Criteria: * Known hypersensitivity to any of the active substances or excipients of the study medication * Antibiotic treatment during the past 8 days or indication for antibiotic treatment for the current infection * Patients with trichomoniasis, chlamydiosis or gonorrhoea * Use of concomitant medication that may have an effect on the UTI, including other phytotherapeutics with similar effects, saluretics (including those in antihypertensives) or other drugs with a similar mode of action, urinary acidifying agents (e.g. Acimethin®), antibiotics, or phytotherapeutics with possible antibiotic effects * Patients with suspected ovarian inflammation (e.g. adnexitis) * Patients with suspected renal inflammation (e.g. pyelonephritis) * Patients with complicated UTI (e.g. obstruction, stones, reflux) * Patients with overactive bladder * Patients with vegetative urogenital syndrome * Patients who were currently participating or had participated in another clinical trial within 30 days before enrolment * Patients in poor general condition * Alcohol- or drug-addicted patients * Pregnant or nursing women or women not using highly effective methods of contraception * Patients with mental illness or no/limited legal capacity * Patients held in an institution by legal or official order * Patients who were not proficient in spoken or written German * Patients with a urine bacterial count \>10\*6 CFU/mL were to be excluded from further participation in the study unless they specifically wished to continue treatment with the study medication. * No contraindications against the study medication were known at the time of study protocol preparation