To Evaluate the Effect of Food on the Pharmacokinetic Characteristics of Alkotinib Capsules in Healthy Subjects

Inclusion Criteria: * sign the informed consent before the clinicaltrial, and fully understand the clinicaltrial content, process and possible adverse event. * Be able to complete the research according to the clinicaltrial protocol. * Subjects (including sexual partners) were willing to be screened up to 6 months after the last study drug administration No family planning and voluntary effective contraceptive measures, the specific contraceptive measures see appendix. * Male and female subjects aged 18 to 55 years (including 18 and 55 years). * The weight of male subjects should not be less than 50 kg and that of female subjects should not be less than 45 kg. The body of the Body mass index (BMI) = weight (kg)/height 2 (m2), with a BMI of 18\~28 kg/m2 range (including critical value). * Normal or abnormal physical examination and vital signs have n * clinical significance. Exclusion Criteria: * Smoking more than 5 cigarettes per day during the first 3 months of the study * Allergic constitution (multiple drug and food allergies). * A history of drug and/or alcohol abuse (14 units of alcohol per week: 1 unit = beer 285)ML, or liquor 25 mL, or wine 100 mL) * Blood donation or massive blood loss within 3 months prior to clinical trial screening (\> 450ml) * Any drugs that alter liver enzyme activity were taken 28 days before screening. * Within 14 days prior to screening，took any prescription, over-the-counter, vitamin products or Herbs. * Special diet (including dragon fruit, mango, grapefruit, etc.) or drama in 2 weeks，before screening strenuous exercise or other factors affecting drug absorption, distribution, metabolism, excretion, etc.; * CYP3A inhibitors (e.g., atanavir, talymycin, clarithromycin, etc.), CYP3A inducers (e.g Drugs metabolized by CYP2C8 (such as amodiaquine, silvastatin, etc.) and CYP2C9 metabolism Drugs such as diclofenac, ibuprofen, etc. * There have been major changes in diet or exercise habits recently. * Have taken a study drug or participated in a clinical trial of the drug within three months prior to taking the study drug Check. * A history of dysphagia or any gastrointestinal illness that affects drug absorption, cholecystitis or cholecystectomy In addition to the history; * Any disease that increases the risk of bleeding, such as hemorrhoids, acute gastritis or stomach and duodenum Ulcer etc. * Subjects who could not tolerate standard meals * Abnormal ecg has clinical significance, or QTc interval \>450 ms, or heart rate or pulse \< 55 times /Points. * Any pulmonary disease, including but not limited to interstitial pneumonia, allergic pneumonia, occlusion.Bronchiolitis, pulmonary interstitial fibrosis,interstitial lung disease (ILD), or any pre-existing disease History. * Female subjects were lactating during the screening period or during the test or had positive serum pregnancy results sex. * Clinical laboratory examination has clinical significance abnormality, or other clinical findings within 12 months before screening the following diseases (including but not limited to gastrointestinal tract, heart, lung, kidney,Liver, pancreas, nerve, blood, endocrine, tumor, immune, mental or cardiovascular diseases）. * Screening for viral hepatitis (including hepatitis b and c), AIDS antibody and syphilis spirochete antibody positive. * Ingested chocolate, any caffeine containing it or the yellow purinate-rich drug 48 hours before taking it. * Any use of alcohol within 48 hours prior to taking the study drug. * Positive urine screening or drug use in the past 5 years. * Subjects considered to have other factors unsuitable for participation in this study.