Exercise Program for Arteriovenous Fistula Maturation

Hospices Civils de Lyon40 enrolled

Overview

Arteriovenous fistula (AVF) is the recommended vascular access for chronic hemodialysis, as it is associated with less mortality and better patency than arteriovenous graft (AVG) or central venous catheter (CVC). Unfortunately, AVF suffers from a high failure rate, due, in part, to poor venous diameter. The aim of this study is to investigate whether a perioperative handgrip training can improve the diameter of AVF in patients with chronic kidney disease (CKD) (stage IV-V).

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

SUPPORTIVE_CARE

Masking

SINGLE

Enrollment

Conditions

Arteriovenous Fistula

Interventions

Handgrip exercise programPROCEDURE

Handgrip exercise with a rubber ball 4 weeks before the surgery until 4 weeks after the surgery 20 contractions per minute for a total of 20 minutes each day.

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients older than 18 years * with chronic kidney disease (Estimated Glomerular Filtration Rate (eGFR) \<30 milliLiter/minute (mL/min)) * with follow-up at the University Hospital of Lyon Sud * who choose hemodialysis as renal replacement therapy Exclusion Criteria: * contraindication for arteriovenous fistula (AVF) surgery * refusing AVF creation * prior vascular access * antecedent of IV substance abuse * active cancer * inability to perform handgrip exercise * physical or mental disability limiting follow-up possibility * inclusion in an other interventional study * no social welfare

Locations (1)

Service de néphrologie, dialyse et nutrition rénale - Centre Hospitalier Lyon Sud

Pierre-Bénite, France

RECRUITING

Outcomes

Primary Outcomes

Arteriovenous Fistula (AVF diameter)

Arteriovenous Fistula diameter will be measured by Doppler ultrasound

Time frame: at 6 weeks (after surgery)

Secondary Outcomes

Echographic maturation rate

Maturation rate of Arteriovenous Fistula (AVF) by echography defined as blood flow\>600milliLiters/minute (mL/min), diameter\>6millimeters (mm) and depth \<6mm

Time frame: at 6 weeks (after surgery)

Clinical maturation rate

Arteriovenous Fistula (AVF) measured by a vein easily palpable, relatively straight, with a uniform sensation of quivering and more than 10centimeters (cm) long.

Time frame: at 6 weeks (after surgery)

Arteriovenous Fistula (AVF) localization (arm or forearm)

After the patient's examination, the vascular surgeon will choose the future AVF localization

Time frame: at 6 weeks (after surgery)

Arteriovenous Fistula (AVF) interventions

Necessity of performing an intervention (such as angioplasty or thrombolysis or thrombectomy or superficialization) on the Arteriovenous Fistula (AVF)

Time frame: up to 6 weeks

Emergency hemodialysis on Central Venous Catheter (CVC)

Necessity of patients on CVC to undergo emergency hemodialysis

Time frame: up to 6 weeks

Emergency hemodialysis on Arteriovenous Graft (AVG)

Necessity of patients on AVG to undergo emergency hemodialysis

Time frame: up to 6 weeks

Central Contacts

Abbas DEEB, PhD

CONTACT

04.72.67.87.03 abbas.deeb@chu-lyon.fr

Data from ClinicalTrials.gov

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