Cohort of Hospitalized Patients Suspected of Leptospirosis

N/AActive Not RecruitingNCT04034550

Institut National de la Santé Et de la Recherche Médicale, France200 enrolled

Overview

COLEPT is a prospective interventional study that intends to better inform about leptospirosis, a neglected zoonotic infectious disease. During prospective follow-up of hospitalized acute leptospirosis cases, the participants will be assessed during 1 year for epidemiological, clinical, bacteriological and immunological data. Main intervention consists in blood sampling and biological bank constitution.

Study Type

INTERVENTIONAL

Allocation

Purpose

SUPPORTIVE_CARE

Masking

NONE

Enrollment

200

Conditions

Leptospirosis

Interventions

Blood and urine sampling and blood bankingOTHER

In routine management, blood and urine will be sampled for each patients and specific analyses carried out. Only blood samples will be banked.

Eligibility

Sex: ALLMin age: 1 DayHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * clinico-biological manifestations compatible with acute leptospirosis OR proven leptospirosis with serological testing or PCR * onset of symptoms within 21 days * participant benefits of health insurance Exclusion Criteria: * participant's refusal, or refusal from his relatives in case of major incapacity of the eligible participant precluding expression of his will (coma, stay in intensive care unit))

Locations (4)

Groupe Hospitalier Est Réunion (GHER)

Saint-Benoît, Reunion, France

CHU de La Réunion site Nord

Saint-Denis, Reunion, France

Centre Hospitalier Ouest Réunion (CHOR)

Saint-Paul, Reunion, France

CHU de La Réunion site Sud (GHSR)

Saint-Pierre, Reunion, France

Outcomes

Primary Outcomes

disease severity

Rate of death or severe organ insuffisiency

Time frame: 0 to 21 days after onset of symptoms

Data from ClinicalTrials.gov

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