CPET in Evaluation of PH in COPD Patients

Overview

* To evaluate the entire course of exercise during CPET in COPD patients. * To study whether CPET, PFTs and arterial blood gases could discriminate between COPD patients with and without PH. * To study whether the existence of pulmonary hypertension in COPD is related to characteristic findings in gas exchange and circulatory parameters during cardiopulmonary exercise testing (CPET).

(COPD) is a common cause of pre-capillary pulmonary hypertension (PH). Pulmonary hypertension (PHT) is a common complication of COPD and is determinant for the prognosis of COPD. PHT is defined as A mean PAP of ≥ 25 mmHg measured by right heart catheterization at rest. Exercise tolerance in patients with COPD is reduced due to ventilatory limitation, gas exchange abnormalities, and deconditioning as the disease progresses, and this may impair functional capacity and the quality of life. COPD patients usually terminate physical activity when the ventilatory requirement exceeds their maximal ventilatory capacity. If they have PH, the altered hemodynamic response may reduce their exercise capacity further. Nowadays, despite the fact that LTOT improves the survival of hypoxaemic patients, PH is still associated with lower survival rates . Importantly, an elevated Ppa was also associated with an increased risk of severe acute exacerbation in COPD patients with moderate-to-severe airflow limitation . Impaired exercise tolerance in COPD patients would suggest that cardiopulmonary exercise test (CPET) is a valuable tool to reveal whether they have PH or not. Transthoracic echocardiography (TTE) is one such tool and is widely available and safe. In addition to its role in diagnosis, it can be used to screen for high-risk patient populations, to assess prognosis and to monitor disease stability and response to treatment.

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