Patients after the Fontan operation at a single institution will be randomized to receive a standardized extract of Aesculus hippocastanum L. (horse chestnut) or placebo for 4 months in a crossover clinical trial. The primary outcome will be the mesenteric artery resistance measured by Dopple sonography.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Treatment for 4 months, washout of 4 weeks, then crossover for another 4 months.
Treatment for 4 months, washout of 4 weeks, then crossover for another 4 months.
Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto
Ribeirão Preto, São Paulo, Brazil
Mesenteric artery resistance
Mesenteric artery resistance, measured by pulsed-wave Doppler, in 0.1 units
Time frame: After 4 months
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