Background An appropriated mechanical ventilator setting for acute respiratory failure results of ventilator associated lung injury. Limited driving pressure and low tidal volume ventilation strategies show benefits decreasing mortality in acute respiratory distress syndrome, but there are no data in simple acute respiratory failure.
Background An appropriated mechanical ventilator setting for acute respiratory failure results of ventilator associated lung injury. Limited driving pressure and low tidal volume ventilation strategies show benefits decreasing mortality in acute respiratory distress syndrome, but there are no data in simple acute respiratory failure. To compare lung injury score (LIS, Murray score) after invasive mechanical ventilation 7 days between groups of limited driving pressure ventilation versus low tidal volume ventilation strategies.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
126
Keep driving pressure \<15 cmH2O
Keep tidalvolume \</= 8
Mahidol university
Bangkok Noi, Bangkok, Thailand
Lung injury score
Lung injury score (LIS, Murray score)
Time frame: Day 7 after invasive mechanical ventilation
28 days Mortality
28 days Mortality
Time frame: Upto 28 days
New onset of ARDS
New onset of ARDS
Time frame: Upto 28 days
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