Development of New Biomarkers With Magnetic Resonance Imaging for Longitudinal Studies in CADASIL Angiopathy

Inclusion Criteria: Patients * Age from 18 to 80 years * Confirmed diagnosis (detection of a pathogenic mutation of the NOTCH3 gene) * Detailed clinical and MRI assessment of the disease (follow-up at the CERVCO) including Rankin score \<4 * Any contraindication to MRI or EEG examination (claustrophobia, presence of material with magnetic properties) * Social security insurance * Written consent. Controls * Age from 18 to 80 years * No history of neurological or psychiatric diseases * No history of migraine with aura * No history of vascular disease (peripheral arteries, heart, brain) * No known or treated diabetes * No known or treated hypercholesterolemia * Social security insurance * Written consent Exclusion Criteria: Patients * Patients with a contraindication to MRI or EEG examination (claustrophobia, material with magnetic properties: pacemaker, ferromagnetic material ...) * For MRI examination of neurovascular coupling: Patients with a treatment that may interfere with neurovascular coupling (in particular any treatment with non-steroidal anti-inflammatory drugs, psychotropic drugs, antihypertensive agents or statins) * Patients without a social security insurance * Patients under the age of 18 or over 80 at the time of the first visit * Patients unable to give their informed consent * Person referred to in Articles L. 1121-5 to L. 1121-8 and L. 1122-12 of the Public Health Code, defined by: * Pregnant, parturient or nursing woman * Person deprived of liberty by judicial or administrative decision * Person hospitalized without consent and not subject to a legal protection measure, and person admitted to a health or social institution for purposes other than research * Minor * Adult under legal protection measure (guardianship, guardianship or court order), an adult unable to express their consent and not subject to a protective measure * Person submitted to an exclusion period for another research (washout period) Controls * Subject with a contraindication to MRI or EEG examination (claustrophobia, material with magnetic properties: pacemaker, ferromagnetic material ...) * For MRI examination of neurovascular coupling: Subject with a treatment that may interfere with neurovascular coupling (in particular any treatment with non-steroidal anti-inflammatory drugs, psychotropic drugs, antihypertensive agents or statins) * Subject without a social security insurance * Subject under the age of 18 or over 80 years at the time of the first visit * Patients unable to give their informed consent * Person referred to in Articles L. 1121-5 to L. 1121-8 and L. 1122-12 of the Public Health Code, defined by: * Pregnant, parturient or nursing woman * Person deprived of liberty by judicial or administrative decision * Person hospitalized without consent and not subject to a legal protection measure, and person admitted to a health or social institution for purposes other than research * Minor * Adult under legal protection measure (guardianship, guardianship or court order), an adult unable to express their consent and not subject to a protective measure * Person submitted to an exclusion period for another research study (washout period)