Evaluating the Safety, Pharmacodynamics and Pharmacokinetics of HSK3486 in Healthy Female Subjects.

Inclusion Criteria: * Female, aged 18 - 49 years (inclusive) * Women of child-bearing potential agreed to use adequate contraception prior to study entry, for the duration of study participation, and for 90 days following completion of therapy * Negative serum pregnancy test * In general good health without CS medical history * American Society of Anesthesiologists (ASA) Physical Status Classification of I or II * Body Mass Index (BMI) between 18 and 30 kg/m2 (inclusive) * Negative screen for drugs of abuse, alcohol, hepatitis B surface antigen (HBs-Ag), hepatitis C virus antibody (HCV-Ab) and Human Immunodeficiency Virus (HIV) at screening; and drugs of abuse, alcohol pre dose on Day -1 * Normal or non-CS findings on a physical examination, 12-lead Electrocardiogram (ECG) and vital signs (respiratory rate between 12 and 20 breaths per minute, blood pressure (BP) between 100-140/60-90 mmHg, heart rate between 50-99 beats per minute, temperature between 35.8°C and 37.5°C and pulse oximetry values \> 95% on room air) * Clinical laboratory values within the normal limits as defined by the clinical laboratory, unless the PI decided that out-of-range values were not CS * Able to provide written informed consent * Willing and able to follow study instructions and likely to complete all study requirements * Suitable venous and arterial access Exclusion Criteria: * History of allergy or sensitivity to: propofol, components of Fresofol 1% MCT/LCT propofol, or HSK3486 (excipients soy bean oil, glycerine, triglycerides, purified egg phospholipids, sodium oleate and sodium hydroxide), or plain lignocaine * History of CS problems with general anesthesia * Current smoker, or a history of regular (more than weekly) use of tobacco- or nicotine-containing products within 2 months prior to screening * History of excessive alcohol intake (more than four standard drinks daily, on average) or use of recreational drugs within the last 3 months CONFIDENTIAL HSK3486 SAD\_02 Sichuan Haisco Pharmaceutical Co., Ltd Version: 13 Nov 2015 Page 19 of 513 * Use of prescription or over the counter medications within 7 days of Investigational Product administration, with the exception of contraceptive medications, paracetamol, oral non-steroidal anti-inflammatory agents, topical over the counter preparations and routine vitamins (if they do not exceed an intake of 20 to 600 times the recommended daily dose), unless agreed as non-clinically relevant by the PI and Sponsor. * Standard donation of blood within 30 days of the study * Donation of plasma or participation in a plasmapheresis program within 7 days preceding this study * Receipt of any investigational study drug within 30 days prior to screening * Unable to fast for the 6 hours prior to Investigational Product administration * CS (as judged by the Investigator) presence of acute illness (e.g. gastrointestinal illness, infection such as influenza, upper respiratory tract infection) at admission to the clinical study unit * Anticipated need for surgery or hospitalization during the study * Anatomical abnormality that would potentially interfere with airway management under unconscious sedation or anesthesia * History of posture-related gastric reflux more than twice weekly * History of seizures or epilepsy * History of ischaemic heart disease * History of brady- or tachy-dysrhythmias requiring medical care * History of asthma, with bronchospasm requiring treatment in the last 3 months * Any condition, which in the Investigator's opinion, puts the subject at significant risk, could confound the study results or may interfere significantly with the subject's participation in the study.