A Renal Impairment Study for PF-06651600

Inclusion Criteria: * Body mass index (BMI) of \>/= 17.5 to \</= 40.0 kg/m2; and a total body weight \> 50 kg (110 lb) Additional inclusion criteria for subjects with renal impairment: * Meet the following eGFR criteria during the screening period based upon MDRD equation: * Severe renal impairment: eGFR \<30 mL/min but not requiring hemodialysis * Moderate renal impairment (Part 2 only): eGFR \>/=30 mL/min and \<60 mL/min * Mild renal impairment (Part 2 only): eGFR between 60 and 89 mL/min * Any form of renal impairment except acute nephritic syndrome (subjects with history of previous nephritic syndrome but in remission can be included) * Stable drug regimen Exclusion Criteria: * Females of child-bearing potential must use an accepted, highly effective contraceptive method * Renal transplant recipients * Urinary incontinence without catheterization * Subjects with clinically significant infections within the past 6 months prior to first dose of study drug, evidence of active or chronic infection requiring oral treatment within 4 weeks prior, history of disseminated herpes simplex or recurrent or disseminated herpes zoster * Subjects with malignancy or with a history of malignancy, with the exception of adequately treated or excised non-metastatic basal cell or squamous cell cancer of skin or cervical carcinoma in situ * HIV, Hepatitis B, or Hepatitis C infection Additional exclusion criteria for subjects with renal impairment: * Subjects requiring hemodialysis and peritoneal dialysis * Screening BP \>/=180 mmHg (systolic) or \>/=110 mmHg (diastolic) * Screening 12-lead ECG demonstrating QTcF \>470 msec