Topical rVA576 for Treatment of Atopic Keratoconjunctivitis

Inclusion Criteria: 1. Aged 18 and above 2. Diagnosis of moderate to severe AKC, VKC, or severe allergic conjunctivitis (seasonal or perennial). Defined as: * AKC, VKC - a composite symptom/sign score from one eye of ≥ 18 out of 33 * Severe allergic conjunctivitis (SAC or PAC) - a composite symptom/sign score from one eye of ≥ 15 out of 27 3. Will have had received some topical therapy during the last 3 months without improvement but will not currently be receiving systemic immunotherapy. Topical therapy may be topical calcineurin inhibitors, antihistamines or corticosteroids alone or in combination. Lubricants or artificial tears will not a count as topical therapy for these purposes. 4. Will have had at least 7 days without topical ocular corticosteroids prior to entry 5. Willing to give informed consent 6. Willing to use highly effective contraceptive precautions for the duration of the study and for 90 days after the last dose of IMP 7. Willing to avoid prohibited medications for duration of study (see list of prohibited medications) Exclusion Criteria: 1. Eye surface disease other than AKC, VKC or severe allergic conjunctivitis (SAC or PAC) 2. Contact lens use during the study 3. Complete or partial tarsorrhaphy. If such a procedure becomes necessary during the course of the trial patients may remain in the trial providing that at least 50% of the eye surface remains visible to slit lamp examination 4. Ankyloblepharon of any degree at entry to the trial 5. Known or suspected ocular malignancy 6. Active ocular infection at entry to the trial. Patients with eye surface bacterial, viral, fungal or protozoal infection may enter the trial after elimination of the infection as confirmed by eye swabs 7. Known or suspected uveitis 8. Participation in any other clinical trial within 1 month of enrolment 9. Use of any of the following prohibited medications: * Eculizumab * Any other investigational complement inhibitor whether systemic or topical (e.g. RA101495) * Montelukast * Zafirlukast * Pranlukast * Zileuton * Hypericum perforatum (St John's wort) 10. Corneal perforation 11. Uncontrolled glaucoma (increase in dose of glaucoma medication or surgical intervention for glaucoma within 3 months prior to entry) 12. Pregnancy (females) 13. Breast feeding (females) 14. Known allergy to ticks or severe reaction to arthropod venom (e.g. bee or wasp venom) 15. Use of topical ocular steroids within 7 days of the Screening visit 16. Failure to satisfy the PI of suitability to participate for any other reason