Preoperative anemia is associated with an important increase in transfusions of red blood cells (RBC) compared to a non-anemic patient in cardiac and non cardiac surgery. Furthermore transfusion is also an independent factor of morbi-mortality with notably an increase in the infectious risk, immunological, an increase of the risk of cardiac decompensation, respiratory decompensation Transfusion Related Acute Lung Injury (TRALI) or Transfusion Associated Cardiac Overload (TACO), and an increase in mortality of 16%. Management of perioperative transfusion is therefore a public health issue. Since 2010, the World Health Organization (WHO) has been promoting a systematic approach to implement blood management programs for the patient to optimize the use of resources and promote quality and safety of care. Improving the relevance of transfusion in cardiac surgery could be achieved by optimizing the management of patients around 2 axis: A:non-drug intervention : Review of Practices to Improve the Management of Perioperative RBC Transfusion B:drug intervention : Systematic correction of pre- and postoperative iron, vitamin deficiencies and anemia The aim of this program is to improve the relevance of transfusion in cardiac surgery and to limit the morbidity and mortality induced by transfusion. This program is part of a global project of pre, per and postoperative management of the patient undergoing cardiac surgery programmed under extracorporeal circulation (ECC). It requires a multidisciplinary approach between cardiologists, anesthesiologists and intensivists, perfusionists, cardiac surgeons and paramedical teams to optimize the management of the patient.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Enrollment
900
Preoperative: For patient with iron deficiency: Intravenous iron supplementation For patient with folic acid or vitamin B12 deficiency : oral vitamin supplementation For patient with anemia: pre operative erythropoietin injections Postoperative: Systematic iron supplementation
Training program to sensitize health care staff to streamline the use of transfusion targeting the following points: limit perioperative and post operative hemodilution; to adapt the transfusion threshold to the tolerance of the patient to anemia in per and postoperative; justify the use of RBC transfusion by setting up a questionnaire; encourage transfusion of RBC unit by unit.
Clinique Pasteur
Toulouse, France
RBC transfusion rate
Proportion of patient who received at least one RBC transfusion during their hospitalization
Time frame: Between surgery and hospital discharge, an average of 10 days
Adverse events
Occurrence of adverse event
Time frame: between baseline (1 month before surgery) and 3 months after surgery
Transfusion parameters
Transfusion rate, use of poly transfusion, hemodilution, transfusion thresholds and postoperative bleeding volume.
Time frame: between surgery and hospital discharge, an average of 10 days
Blood test parameters
hemoglobin, ferritin
Time frame: between baseline (1 month before surgery) and 3 months after surgery
6 min walk test
Walking test : distance reach after 6 min
Time frame: at discharge of the healthcare and rehabilitation units
New York Heart Association (NYHA)
NYHA Functional Classification
Time frame: between baseline (1 month before surgery) and 3 months after surgery
Euro Quality of life 5 dimensions (EQ5D)
EQ5D Quality of life questionnaire
Time frame: between baseline (1 month before surgery) and 3 months after surgery
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