This trial is a set of four independent experiments involving for each of them functional and structural MRI data acquisition. They aim at investigating decision making mechanisms in bulimia nervosa when participants have to make food or monetary choices under specific conditions that mimic binge eating episodes or kleptomania which are two major symptoms of bulimia nervosa. All experiments are cross sectional studies. Each experiment is subdivided into two parts: a first part without any MRI data acquisition and during which all the tasks are performed. This part aims at making sure that a behavioral effect is observed before starting MRI data acquisition. The second part aims at investigating the neural correlates observed in the first part and additionally, at reproducing the behavioral effects observed in the first part. Therefore the first part may be regarded as an independent study as compared to the second part.
Each part of each experiment is built of a main task, a set of secondary tasks and questionnaires. Only the main task changes from one experiment to another. Within each experiment, the only difference between the two parts is that the main task is performed while participants are being scanned in an MRI scanner. Details of the tasks are provided below. Each part of each experiment is performed over one visit only and is a cross sectional study. The visit is dedicated to the tasks. Questionnaires may be filled during the visit or at participant's home within the week following the visit for questionnaires which are not assessing participant's state. Questionnaires assessing participant's state are filled during the visit at appropriate time. The total number of participants mentioned below is the sum of the planned number of participants within each group, i.e. patients and healthy participants, within each part of each experiment.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
59
Each of the 4 experiments is built of a main task. The first task involves a first phase of subjective valuation of food items. The second phase requires from the participant to make a choice between two out of three food items selected by the computer.
Each of the 4 experiments is built of a main task. The first task involves a first phase of subjective valuation of food items. The second phase requires from the participant to make a choice between two out of three food items selected by the computer.
Hopital Vinatier
Lyon, Auvergne-Rhône-Alpes, France
oxygen variation in the brain
Brain activity related to task performance collected in the MRI scanner.Blood Oxygen Level Dependent response synchronized with any event of interest during the task. Events of interests are: * Onset time of any visual stimulus * Onset time of any response of the participant.
Time frame: 10 days
Task related parameters
reaction times computed as the duration in ms between the onset time of the stimulus and the onset time of the participant's answer. Several tasks may be involved in each experiment including in the MRI scan. These rules apply to all tasks.
Time frame: 10 days
Skin conductance response related to events in the task performed while the signal is being collected
Skin conductance response in microSiemens synchronized with any event of interest during the task. Events of interests are: * Onset time of any visual stimulus * Onset time of any response of the participant
Time frame: 10 days
cardiac frequency in beats per minute related to events in the task performed while the signal is being collected
cardiac frequency is computed from the pulse plethysmogram sensor signal while the participant is performing the task. Task during which this signal is collected may be one of the tasks performed in the scanner as well as tasks performed outside the scanner.
Time frame: 10 days
parameters of eye movements extracted from the eye tracking signal is being collected
The parameters computed are X and Y position of the eye by amplitude of variation of pupil size over a time window synchronized with events in the task
Time frame: 10 days
Eating Disorders Examination (EDE-Q)
The EDE is a semi-structured interview conducted by a trained clinician to assess the psychopathology associated with the diagnosis of an eating disorder. The EDE is rated through the use of four subscales (restraint, eating concern, weight concern, shape concern) and global score.
Time frame: 10 days
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