The implementation of nutritional strategies targeting several variables at once could benefit patients with cirrhosis. Non-alcoholic beer has different compounds derived from hops that exert antioxidant, anti-inflammatory and nutritional properties. The aim of this study is to evaluate the effect of diet + exercise and non-alcoholic beer on nutritional status, endothelial function and quality of life in patients with cirrhosis.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
42
Treatment consisted of 330ml non-alcoholic beer per day, plus an individualized dietary program and an exercise program with a pedometer-based bracelet to reach at least 5000 steps/day during 2 + 8 weeks.
Treatment consisted of 330ml of water, plus an individualized dietary program and an exercise program with a pedometer-based bracelet to reach at least 5000 steps/day during 2 + 8 weeks.
Nutritional status
improvement in impedance-derived phase angle (PhA)
Time frame: 8 weeks
Endothelial function
improvement in flow-mediated dilation (brachial artery)
Time frame: 8 weeks
Endothelial dysfunction
improvement in serum markers of endothelial function (v.gr. nitric oxide, NO; prostacyclin, PGI2, etc.)
Time frame: 8 weeks
Quality of life questionnaire
Improvement in quality of life questionnaire CLDQ (chronic liver disease questionnaire)
Time frame: 8 weeks
Changes in the heterogeneity of gut Microbiota
Changes in the heterogeneity of fecal microbiota in terms of bacterial diversity will be assessed
Time frame: 8 weeks
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