ICU-acquired Colonization and Infection Related to MDR in Immunocompromised Patients

University Hospital, Lille759 enrolled

Overview

the number of immunocompromised patients hospitalized in the intensive care units (ICU) is increasing. They are at higher risk of colonization and/or infection with multi-resistant bacteria (MDR). However this risk is not well characterized. ICU acquired infections related to MDR are associated with increased morbidity and mortality. The aim of this study is to compare the incidence of ICU-acquired colonization and ICU-acquired infection related to MDR between immunocompromized and immunocompetent patients. The risk factors for ICU-acquired colonization and ICU-acquired infections, and their impact on outcome will also be evaluated and compared between immunocompromised and immunocompetent patients.

Study Type

OBSERVATIONAL

Enrollment

759

Conditions

Immunocompromised Host Critical Care

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Expected ICU stay \> 48 hours * All patients (immunocompromised or immunocompetent). Exclusion Criteria: * Patients aged \< 18 years * Refusal to take part in the study * ICU-stay \< 48 hours * Non availability of initial MDR or subsequent screening * Participation in another study that could interfere with the risk of ICU-acquired colonization and infection with MDR bacteria

Locations (7)

Chu Amiens Picardie

Amiens, France

Ch Bethune

Béthune, France

Grand Hopital de L'Est Francilien

Jossigny, France

CH LENS

Lens, France

Hôpital Roger Salengro, CHU

Lille, France

Hospices Civils de Lyon

Lyon, France

C.H de Roubaix

Roubaix, France

Outcomes

Primary Outcomes

Density rate of ICU-acquired infections related to MDR in immunosuppressed patients.

the number ICU-acquired infections related to MDR will be devided by the number of days in the ICU and reported for 1000 days.