Salivary cortisol is used as a diagnostic analysis in the investigation of suspected Cushings' syndrome. This study evaluates if liqourice intake increases salivary cortisol in healthy individuals. Late night salivary cortisol and cortisone is analysed before, during and after 7 days of liqourice intake in three different doses.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
DIAGNOSTIC
Masking
NONE
Enrollment
30
Liqourice corresponding to 1.5, 3.0 or 6.0 mg glycyrrhizic acid per kg body weight is taken in the evening during 7 days.
Department of Public Health and Clinical, Umeå University
Umeå, Sweden
RECRUITINGLate night salivary cortisol
Significantly increased salivary cortisol 23:00 PM compared to baseline (i.e. before start of liqourice intake).
Time frame: day 1 to day 7 during liqourice intake
Time to normalization of late night salivary cortisol
Time from liqourice intake is stopped until significant increase of late night salivary cortisol from baseline (i.e. assuming outcome 1 is significant increase) is no longer significant.
Time frame: 1-28 days efter liqourice intake is stopped
Morning salivary cortisol
Significantly increased salivary cortisol 08:00 AM compared to baseline (i.e. before start of liqourice intake).
Time frame: day 1-2 during liqourice intake
Late night salivary cortisol/cortisone ratio
Significantly increased salivary cortisol 23:00 PM compared to baseline (i.e. before start of liqourice intake).
Time frame: day 1 to day 7 during liqourice intake
Time to normalization of late night salivary cortisol/cortisone ratio
Time from liqourice intake is stopped until significant increase of late night salivary cortisol from baseline (i.e. assuming outcome 1 is significant increase) is no longer significant.
Time frame: 1-28 days efter liqourice intake is stopped
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