Diaphragm Ultrasound in Neuromuscular Disorders

Centre d'Investigation Clinique et Technologique 8051,000 enrolled

Overview

Muscular dystrophies are neurologic disease with higher morbidity and mortality. Cardiac function and respiratory muscles can be affected, in addition with skeletal muscle deficiency . Lung function is classically assessed with functionnal pulmonary tests (FPT) . Ultrasound recently emerged as a non-invasive tool to assess diaphragm function. The aims of the study are: * to provide the spectrum of diaphragm ultrasound in patients with muscular dystrophies * to assess the correlation between diaphragm ultrasound and FPT * to assess the correlation between diaphragm ultrasound and cardiac function

Study Type

OBSERVATIONAL

Enrollment

1,000

Conditions

Muscular Dystrophies

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Inclusion Criteria: * Duchenne muscular dystrophy, * Becker muscular dystrophy, * LGMD, * myotonic dystrophy type 1 and type 2, * metabolic myopathy, * mitochondrial myopathy, * FSHD1 and 2, * myasthenia Exclusion Criteria: * history of cardiac surgery * history of thoracic surgery * brain traumatism

Locations (1)

Hopital Raymond Poincare

Garches, France

Outcomes

Primary Outcomes

diaphragm ultrasound motion

using echography

Time frame: 1 year

Secondary Outcomes

correlation between diaphragm motion (mm) and forced vital capacity(ml)

using echography and FPT

Time frame: 1 year

correlation between diaphragm motion (mm) and inspiratory capacity (ml)

using echography and FPT

Time frame: 1 year

diaphragm thickness (mm)

using echography

Time frame: 1 year

correlation between diaphargm thickness and maximal inspiratory pressure (cmH20)

using echography and FPT

Time frame: 1 year

Data from ClinicalTrials.gov

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