This prospective study will explore the pharmacokinetic exposure and pharmacodynamics of the echinocandins (caspofungin or anidulafungin) in critically ill patients.
This non-randomized, monocenter pharmacokinetic study will be carried out in critically ill patients receiving multiple dose treatment with echinocandins (caspofungin or anidulafungin). The pharmacokinetics and pharmacodynamics of the echinocandins in plasma and BAL will be determined. Especially, the relative contributions of two pathophysiological alterations (capillary leak and hypoalbuminemia) encountered in critically ill patients, will be explored. Also other correlating covariates will be identified to provide a rationale for optimal dosing strategy in critically ill patients.
Study Type
OBSERVATIONAL
Enrollment
60
Plasma and BAL sample collection
UZ Leuven
Leuven, Belgium
RECRUITINGArea under the curve (AUC)
The area under the concentration-time curve will be calculated
Time frame: July 2020
Half-life (T1/2)
The half-life will be calculated
Time frame: July 2020
Volume of distribution (Vd)
The volume of distribution will be calculated
Time frame: July 2020
Clearance (CL)
The clearance will be calculated
Time frame: July 2020
Maximum plasma concentration
The median maximum plasma concentration will be reported
Time frame: July 2020
Minimum plasma concentration
The median minimum plasma concentration will be reported
Time frame: July 2020
Average plasma concentration
The average plasma concentration will be calculated
Time frame: July 2020
Influence of serum creatinin (mg/dL) on echinocandin-exposure
Time frame: July 2020
Influence of glomerular filtration rate (ml/min) on echinocandin-exposure
Time frame: July 2020
Influence of on bilirubin on echinocandin-exposure
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Time frame: July 2020
Influence of gamma-GT on echinocandin-exposure
Time frame: July 2020
Influence of alkaline phosphatase on echinocandin-exposure
Time frame: July 2020
Influence of AST on echinocandin-exposure
Time frame: July 2020
Influence of ALT on echinocandin-exposure
Time frame: July 2020
Influence of SOFA ( sequential organ failure assessment) score on echinocandin-exposure
Time frame: July 2020
Influence of APACHE II (Acute Physiology and Chronic Health Evaluation II) score on echinocandin-exposure
Time frame: July 2020
Influence of total protein on echinocandin-exposure
Time frame: July 2020
Influence of serum albumin on echinocandin-exposure
Time frame: July 2020
Influence of Ang-1 on echinocandin-exposure
Time frame: July 2020
Influence of Ang-2 on echinocandin-exposure
Time frame: July 2020
Influence of VEGF on echinocandin-exposure
Time frame: July 2020
Influence of inflammation (CRP) on echinocandin-exposure
Time frame: July 2020
Influence of fluid balance (mL) on echinocandin-exposure
Time frame: July 2020
Influence of prothrombin time on echinocandin-exposure
Time frame: July 2020