The purpose of this randomized clinical trial is to examine the effects of Mediterranean diet based intervention on inflammation and metabolic risk factors in overweight or obese postmenopausal women with breast cancer receiving adjuvant hormone therapy.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
SINGLE
Enrollment
78
Two meals (breakfast and dinner) a day, five times a week, are delivered to participants' homes without charge. The meals are prepared, under the supervision of an expert nutritionist, by a chef trained on the principles of the Mediterranean diet.
Change in C-Reactive Protein (CRP) levels
Blood will be drawn from the participants for assessment of CRP levels (mg/L)
Time frame: Baseline, 8 weeks
Change in fasting insulin levels
Blood will be drawn from the participants for assessment of fasting insulin levels (mcIU/mL) after fasting for at least 8 hours
Time frame: Baseline, 8 weeks
Change in fasting glucose levels
Blood will be drawn from the participants for assessment of fasting glucose levels (mg/dL) after fasting for at least 8 hours
Time frame: Baseline, 8 weeks
Change in lipid profile
Blood will be drawn from the participants for assessment of total cholesterol, triglyceride, HDL-cholesterol, and LDL-cholesterol (mg/dL) after fasting for at least 8 hours
Time frame: Baseline, 8 weeks
Change in body weight
We will measure body weight (kg) of participants using the same scale
Time frame: Baseline, 8 weeks
Change in fat mass measured by bioelectrical impedance analyzer
We will measure fat mass (kg) using bioelectrical impedance analyzer
Time frame: Baseline, 8 weeks
Change in quality of life assessed by EORTC QLQ-C30 questionnaire
Quality of life will be assessed by questionnaire, named European Organisation for Research and Treatment of Cancer quality of life questionnaire (EORTC QLQ-C30), score range 0\~100, higher scores indicate better quality of life
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Time frame: Baseline, 8 weeks
Change in quality of life assessed by OP scale questionnaire
Quality of life will be assessed by questionnaire, named Obesity-related problems scale (OP scale), scale range 0\~100, higher scores indicate more problems
Time frame: Baseline, 8 weeks