Impedance Spectroscopy in Esophageal Cancer

Sana Klinikum Offenbach67 enrolled

Overview

Detection of early esophageal cancer in surrounding normal tissue can be challenging even for experienced examiners. The early detection is essential to determine the following treatment. Early stages of esophageal cancers can be treated by endoscopic resection whereas advanced neoplasia might lead to an Operation of the esophagus. Diagnosis is made usually by biopsies of suspicious lesions or untargeted quadrant biopsies. The electrical properties in inflammatory tissue and cancer can be sensed by electrical bioimpedance technique. The aim of this study is to compare the impedance probe with the histological result and to investigate the feasibility of the new technique in detection of esophageal cancer.

Detection of early esophageal cancer in surrounding normal tissue can be challenging even for experienced examiners. The early detection is essential to determine the following treatment. Early stages of esophageal cancers can be treated by endoscopic resection (ER) whereas advanced neoplasia might lead to esophagectomy. Diagnosis is made usually by biopsies of suspicious lesions or untargeted quadrant biopsies. The electrical properties in inflammatory tissue and dysplasia can be sensed by electrical bioimpedance technique. The aim of this study is to compare the impedance probe with the histological result and to investigate the feasibility of the new technique in detection of esophageal cancer.

Study Type

INTERVENTIONAL

Allocation

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

Conditions

Cancer of Esophagus

Interventions

impedanceDEVICE

After endoscopic resection of early esophageal cancer, the tissue will be measured by an impedance probe between 10Hz-1000000Hz, 20mV. 8 gold electrodes have been integrated to the probe. The impedance will be measured in different ways between the elctrodes. There will be 10 measurements in total for each specimen.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 99 Years

Medical Language ↔ Plain English

Inclusion Criteria: Known esophageal cancer and planned for endoscopic resection Exclusion Criteria: 1. Missing consent / agreement 2. Patient in bad condition for endoscopy or endoscopic resection 3. Patients with coagulopathy or anticoagulative medication which is a contraindication for endoscopy

Locations (1)

Sana Clinic Offenbach

Offenbach, Hesse, Germany

Outcomes

Primary Outcomes

impedance

value of 17 different frequencies in ohm

Time frame: 10 min

Secondary Outcomes

differences in impedance

Differences in electrical impedance properties between different stages of early esophageal cancer.

Time frame: 10 min

Data from ClinicalTrials.gov

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