The researchers are trying to develop an allergy skin test to help predict allergic responses to medications commonly given to patients during surgery.
This study will be a prospective study to accurately determine the negative predictive value of skin testing with NMBAs. It is hypothesized that the concentrations that should be used for NMBAs are actually much lower than previously recommended and that the higher incidence of identifiable NMBA induced allergic reactions during anesthesia in the past may be due to irritation of the skin rather than a true allergic reaction (false positives).
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
DIAGNOSTIC
Masking
NONE
Enrollment
187
Percutaneous skin prick followed by Intradermal Injections of NMBAs at increasing concentrations compared with an established positive and negative control.
Mayo Clinic
Jacksonville, Florida, United States
Non-Irritant Concentrations to common NMBAs
Determine the NIC to common NMBAs
Time frame: 1 Year
Negative Predictive Value of Intradermal Skin Testing to commonly used NMBAs
Determine Negative Predictive Value of Intradermal Skin Testing to commonly used NMBAs
Time frame: 1 Year
Max Concentration used when skin testing to NMBAs
Close gap on the variability of the maximal concentration used when skin testing NMBAs.
Time frame: 1 Year
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