In the DISCO-TWIN study (prospective, open-label molecular-genetic study), twin pairs with one healthy and one affected twin with molecularly undiagnosed diseases will be analysed by means of omics technologies and/ or re-analysed using existing datasets. Phenotype and omics data will be shared within the University Hospital Tübingen and with external collaborators to improve the diagnostic rate of the subjects included in the study.
Study Type
OBSERVATIONAL
Enrollment
50
Blood take for genetic diagnostic.
University Hospital Tübingen
Tübingen, Germany
RECRUITINGNumber of new Candidate Genes
Number of new Candidate Genes for complex or serious diseases through a comparative genetic analysis of monozygotic clinically discordant twins
Time frame: Day 1
Number of putative disease causes
Number characterizations of the identified putative disease causes.
Time frame: Day 1
Number of diagnosis
Number of patients receiving appropriate therapy after successful diagnosis
Time frame: Day 1
Number of molecular causes of diagnostically unclear rare diseases
Number of molecular causes of diagnostically unclear rare diseases
Time frame: Day 1
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