Influence of High Vitamin C Dose on Lactate During and After Extracorporeal Circulation

University Medical Centre Maribor70 enrolled

Overview

The aim of our study is to find out whether high doses of vitamin C before cardiopulmonary bypass and during the first 24 hours after that have and impact of lowering the incidence of hyperlactatemia.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

SUPPORTIVE_CARE

Masking

TRIPLE

Enrollment

Conditions

Hyperlactatemia Cardiac Disease Bypass Complication Valve Disease, Heart Vitamin C

Interventions

ascorbic acid,DIETARY_SUPPLEMENT

The vitamin C group will get high dose of intravenous vitamin C (ascorbic acid) before starting cardiopulmonary bypass, before removing aortic clamp and every 8 hours thereafter for additionaly 24 hours

Placebo (saline)OTHER

The placebo group will get saline before starting cardiopulmonary bypass, before removing aortic clamp and every 8 hours thereafter for additionaly 24 hours

Eligibility

Sex: ALLMin age: 18 YearsMax age: 100 Years

Medical Language ↔ Plain English

Inclusion Criteria: * \> 18 years old patients with cardiac disease needing surgery (coronary bypass, valve replacement) Exclusion Criteria: * dementia * kidney stones * dialysis * haemochromatosis * thalassemias * G-6-P deficiency

Locations (1)

Department od anesthesiology, intensive care and pain management

Maribor, Slovenia

Outcomes

Primary Outcomes

Concentration of lactate

Measuring the concentration of lactate before cardiopulmonary bypass, after aortic clamp removal, at ICU admission,then every 6 hours

Time frame: up to 30 hours

Secondary Outcomes

dose of noradrenaline and other vasopressors

The need for noradrenaline and other vasopressors (e.g. vasopresin) during the surgery and in the 24-hours after the end of the surgery

Time frame: up to 36 hours

Data from ClinicalTrials.gov

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