We implement a prospective, randomized, unblinded, non-inferiority trial regarding the duration of systemic, targeted antibiotic therapy after the first surgical debridement for spine infection; randomizing 1:1 between 1. Six and twelve weeks of antibiotic therapy if there is an implant left in place 2. Three and six weeks of antibiotic therapy if there is no implant left
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
236
antibiotic therapy for spine infections. 3 vs 6 weeks if no implant left in place. 6 vs 12 weeks if implant left in place. The antibiotic agents used are officially indicated for orthopedic infections, including spine infections and available in Switzerland since decades. Standard dosing will be applied and only modified according to the patient's co-morbidities, intolerances and weight.
Balgrist University Hospital
Zurich, Canton of Zurich, Switzerland
RECRUITINGRemission of infection at 12 months after treatment
no clinical and microbiological recurrences
Time frame: 12 months after treatment
costs
total costs for treatment of infection
Time frame: up to 12 months
duration of sick leave
duration of sick leave for treatment of infection
Time frame: up to 12 months
length of hospital stay
number of days of hospital stay
Time frame: up to 12 months
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