This study seeks to determine whether artificial sweeteners in the context of diet soda may alter the brain's response to food cues and thus impact appetite.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
OTHER
Masking
NONE
Enrollment
5
12 oz can of artificially sweetened cola beverage (Diet Coke planned to be used but similar to Diet Pepsi or other Diet Colas)
12oz can of regular cola beverage (Coke planned but similar to Pepsi or other regular cola sodas)
12oz can of carbonated water (sparking water, selzter water) unflavored
Beth Israel Deaconess Medical Center MRI Research Facility
Boston, Massachusetts, United States
Changes in Brain Response to Food Cues in the Insula
Functional magnetic resonance imaging (BOLD signals) while patients view food vs. non-food cues. The effect size z-score represents the magnitude of the activation in that area to food cues vs. non-food cues. The z-score is the estimated response magnitude in that area compared to the overall mean. Negative numbers indicate values lower than the mean and positive numbers indicate values above the mean.
Time frame: 1 hour
Neurocognitive Testing (Stop Signal Reaction Time)
stop signal reaction time is a measure of inhibitory control, where a shorter stop signal reaction time indicates greater inhibitory control.
Time frame: 1 hour
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