Efficacy and Safety of CHF 6532 in Patients With Uncontrolled Severe Eosinophilic Asthma

Inclusion Criteria: * Male or female subjects aged ≥12 years and ≤75 years with a diagnosis of asthma \[according to Global Initiative for Asthma (GINA)\] for a period of at least 24 months prior to screening. * Subjects treated according to GINA step 4/5 with stable high-dose inhaled corticosteroids (ICS) plus a long-acting β2 agonist (LABA) * 2 Asthma exacerbations history. * A positive response to a reversibility test at screening. * Subjects with evidenced eosinophilic airway inflammation at screening visit. * Subjects with uncontrolled asthma as evidenced by ACQ-5 score ≥1.5 at screening and randomisation visits. * Subjects with co-operative attitude and ability to perform all trial related procedures. * Ability of patient to swallow tablets. Exclusion Criteria: * Pregnant or lactating women and all women of childbearing potential unless are using a highly effective birth control method. * Run-in compliance \< 50% at randomisation * Hospitalisation, emergency room admission or use of systemic corticosteroids for an asthma exacerbation or respiratory tract infection in the 4 weeks prior to screening visit or during the run-in period. * Subjects with a history of near fatal asthma or of a past hospitalisation for asthma in intensive care unit which, in the judgement of the investigator, may place the subjects at undue risk. * Subjects with a history of more than 2 episodes of confirmed bacterial lower respiratory tract infection within the year prior to screening or with a bacterial lower respiratory tract infection during the run-in. * History of diagnosis of Chronic Obstructive Pulmonary Disease (COPD), cystic fibrosis, bronchiectasis or alpha-1 antitrypsin deficiency, or any other significant lung disease which may interfere with study evaluations. * Subjects with a marked resting baseline prolongation of mean QTc interval. * Subjects with a family history of long QT Syndrome. * Subjects with hypokalemia at screening. * Subjects who have known clinically significant cardiovascular conditions. * Subjects with a history of symptoms or significant neurological disease. * Subjects with clinically significant abnormal serum biochemistry, haematology (not associated with the study indication) at screening according to the investigators judgement. * Current smokers or ex-smokers with total cumulative exposure ≥10 pack-years or having stopped smoking less than one year prior to screening visit. * Subjects with historical or current evidence of uncontrolled concurrent disease. * Subjects with a history of hypersensitivity and/or idiosyncrasy to any of the test compounds or excipients employed in this study. * Subjects receiving treatment with any drug known to have a well-defined potential for hepatotoxicity within the previous 3 months before the screening visit. * Subjects receiving treatment with one or more drugs listed in the prohibited medication section. * Regular use of oral or systemic corticosteroids for diseases other than asthma within the past 12 months or any intra-articular or short-acting, intramuscular corticosteroid within 1 month or intramuscular, long-acting depot corticosteroids within 3 months prior to screening. * Subjects with severe hepatitis chronic active hepatitis or evidence of uncontrolled chronic liver disease. * Subjects with Alanine Aminotransferase (ALT) or Aspartate Aminotransferase (AST) at screening ≥2x Upper Limit of Normal. * Subjects with other severe acute or chronic medical or malignancy or psychiatric conditions which are uncontrolled or laboratory abnormality that may increase the risk associated with study participation or study drug administration or may interfere with the interpretation of study results and, would make the subjects inappropriate for entry into this study. * Subjects with a history of lung volume resection. * Subjects with a diagnosis of lung cancer or a history of lung cancer. * Subjects with active cancer or a history of cancer (other than lung) with less than 5 years disease free survival time (whether or not there is evidence of local recurrence or metastases). Localised carcinoma (e.g. basal cell carcinoma, in situ carcinoma of the cervix adequately treated) is acceptable. * Subjects who have received an investigational drug within 30 days (60 days for biologics) or five half-lives (whichever is greater) prior to screening visit. * Subjects with a history of alcohol or drug abuse within two years prior to screening visit. * Subjects with major surgery in the 3 months prior to screening visit or planned surgery during the trial. * Subjects mentally or legally incapacitated or subjects accommodated in an establishment as a result of an official or judicial order.