Decitabine Combined With Oxaliplatin in Patients With Advanced Renal Cell Carcinoma

Inclusion criteria 1. Age: 18 \~75 years old. 2. Patients who are diagnosed pathologically with relapsed/metastatic renal cell carcinoma have a disease progression on standard of care. 3. Performance status: Eastern Cooperative Oncology Group performance status ≦2. 4. Life expectancy more than 3 months. 5. Patients have adequate organ function, accord with following criteria: A. blood routine: Hemoglobin≥90g/L, absolute neutrophil count≥1.5×109/L, platelet count ≥ 80×109/L; B. Biochemical tests: total bilirubin is less than 1.5 times upper limit of normal, alanine aminotransferase and aspartate aminotransferase are less than 2.5 times upper limit of normal; C. creatinine less than 1.25 times upper limit of normal. 6. Patients agree to use adequate contraception in the period of trial and need negative pregnancy test in childbearing potential women. 7. Patients agree to receive treatment with epigenetic drugs. 8. Participant sign an institutional review board-approved, protocol-specific informed consent form in accordance with institutional guidelines. Exclude criteria: 1. Female patients who are pregnant or breast feeding, or adults of reproductive potential who are not using effective birth control methods. 2. Organs failure. 3. ECOG \>2. 4. Serious/active infection. 5. Autoimmune disorders or immunodeficiency diseases. 6. Patients with allergic constitution, or other disease need take drugs of immunosuppressant or corticosteroids. 7. Uncontrolled hypertension. 8. Myocardial ischemia (more than grade II ) or myocardial infarction or uncontrolled arrhythmia. 9. Cardiac insufficiency of grade III to IV according to NYHA criteria, or left ventricular ejection fraction (LVEF) \<50%. 10. Coagulation disorders, tendency of haemorrhage, undergoing thrombolytic or anticoagulant therapy. 11. Unhealed wounds, or fractures. 12. With a history of psychotropic drug abuse or mental disorders. 13. Prior systemic therapies with any antitumor agents within 4 weeks. 14. With other uncurable cancers simultaneously.