Heterotopic Ossification in Abdominal Incision and Pancreatic Cancer

Nanjing Medical University105 enrolled

Overview

To investigate whether pancreatic cancer is the cause of heterotopic ossification of abdominal incision.

Heterotopic ossification of abdominal incision (HOAI) has long been regarded as a rare complication after general surgery. However,according to our retrospective analysis. HOAI was more frequently observed in the malignancy group (33/121 cases, 27.3%) than in the non- malignancy group. Because of the many biases in the retrospective analysis, the result was not widely shared. The purpose of this prospective study is to confirm that pancreatic cancer is the cause of heterotopic ossification of abdominal incisions. According to postoperative pathology, the patients were divided into two groups: pancreatic cancer group and benign diseases group.The researchers will observe whether patients develop heterotopic ossification of the abdominal incision one year after surgery to conclude.

Study Type

OBSERVATIONAL

Enrollment

105

Conditions

Cancer of Pancreas Ossification, Heterotopic

Interventions

Bone alkaline phosphataseDIAGNOSTIC_TEST

Hematologic indicators reflecting ossification.

Abdominal CT scanRADIATION

Observe whether HOAI occurs.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Obtain informed consent from the patients. * The patient's abdominal incision was double-closed with continuous suture of linea alba and fascia with absorbable suture, and skin was sutured with skin staples. Exclusion Criteria: * Refusing to join the study * Previous history of malignant tumor * Previous history of midabdominal incision * Abnormal calcium and phosphorus metabolism * Distant metastasis * Palliative operation * performing neoadjuvant chemotherapy

Locations (1)

The first affiliated hospital of Nanjing Medical University

Nanjing, Jiangsu, China

Outcomes

Primary Outcomes

Incidence of HOAI

HOAI is determined by CT, whose CT number is similar to that of the same spine.

Time frame: 12 months

Bone alkaline phosphatase

Preoperative tests were performed and every three months postoperatively

Time frame: 12 months

Secondary Outcomes

Incidence of distant metastasis and local recurrence

Patients with pancreatic cancer were divided into HOAI and non-HOAI groups to determine whether there were differences in the incidence of distant metastasis and local recurrence between the two groups.

Time frame: 12 months

Central Contacts

Jishu Wei, MD,PhD

CONTACT

086-025-68136891 weijishu@njmu.edu.cn

Data from ClinicalTrials.gov

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