Acute Neural and Immune Effects of Alcohol in People Living With HIV Infection

General Inclusion Criteria: 1. 21-60 years old; 2. Able to speak and read English at least at 8th grade level; 3. Alcohol use ≥.60 g/kg at least once in past year. In standard drinks, this amount translates to 1.9-3.0 drinks for an average-weight female and 2.4-3.9 drinks for an average-weight male. 4. Body mass index of 18.5-34.9 kg/m2; 5. Lab tests obtained in past year showing no evidence of acute/chronic Hepatitis B or C infection; 6. HIV-1 serostatus (positive or negative, depending on group) confirmed by standard clinical testing; 7. Able to consume soy and nuts safely (in order to consume the standardized meal). General Exclusion Criteria: 1. History of heavy drinking on a weekly or more frequent basis, with heavy drinking defined per NIAAA guidelines (≥4 drinks for women, ≥5 drinks for men on a given day), in the past two years; 2. More than five heavy drinking episodes in past 90 days; 3. Seeking or receiving treatment for alcohol/drug use, with exception of smoking cessation treatment; 4. Antibiotic use in past 1 month; 5. Daily use of non-steroidal anti-inflammatory drugs, which are known to increase gut permeability; 6. Disorder of the lower GI tract (e.g., inflammatory bowel disease, ulcerative colitis); 7. Positive urine test for amphetamine, cocaine, methamphetamine, opioids, or benzodiazepines (cannabis use will be assessed but is not an exclusion criterion); 8. Positive screening for past 12-month drug use disorder, indicated by Drug Abuse Screening Test-10 score \>2; 9. Current major psychiatric disorder (current major depressive episode, bipolar disorder, psychotic disorder); 10. History of fainting, weakness, infection, excessive bruising, or extreme distress from blood draw; 11. Safety contraindication for MRI (e.g., metal implant); Note: copper intrauterine devices (IUDs) continue to be excluded due to Brown MRI research facility regulations but other non-metal IUDs are allowed; 12. Head trauma with loss of consciousness \>10 min; 13. Inability to abstain from nicotine for 8 hours in-session; 14. For cannabis users: inability to abstain for 48 hours prior to study; 15. Pregnant, breastfeeding, or not using effective birth control; 16. Any other clinical condition or therapy that, in the physician's opinion, would make subject unsuitable for study or unable to comply with dosing requirement. HIV-Specific Inclusion Criteria: 1. On antiretroviral therapy (ART) for ≥6 mos; 2. Labs in past 6 mos showing viral load \<100 copies/mL, hemoglobin ≥10.0 g/dL, neutrophil count ≥1,000 cells/μL, and platelet count ≥150,000/μL; 3. No active AIDS diagnosis.