Currently, controlled studies are lacking which test the benefits of: 1) ω3 PUFA; and 2) heat therapy on improving vascular-metabolic-microbiota health in Hispanic American populations. The investigator's objective is to determine if this modality (heat therapy i.e., warm water immersion, hot tubs) combined with dietary interventions (increased fish and/or fish oil intake) may be feasible treatments to improve cardiovascular risk factors and reduced comorbidities in Hispanic populations.
In a double-blind, placebo-controlled design, participants will be randomized to the following experimental treatments: 1. 4 g omega 3 daily for 12 weeks combined with 6 weeks of heat therapy 2. Placebo pill daily for 12 weeks with 6 weeks of heat therapy (HT) non-obese healthy will only serve as controls and enroll in placebo and neutral control therapy conditions. HT will entail 14 consecutive days of 1.5 hours passive heating (increase internal temperature 1.2°C above baseline), followed by 4 weeks of HT, 3 days per week.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
60
Active: 1.25 g capsules/420 35-count bottles \[1.25 g capsule contains min. 750 mg EPA + 250 mg DHA\] and heat therapy, increase internal body temperature 1.2 C above baseline. Placebo: 14,700 1.25 g capsules/420 35-count bottles \[1.25-gram high oleic safflower oil capsule\]
Active: 1.25 g capsules \[1.25-gram high oleic safflower oil capsule\] and heat therapy, increase internal body temperature 1.2 C above baseline.
Eric Rivas
Lubbock, Texas, United States
RECRUITINGMetabolic flexibility
Mixed meal tolerance test
Time frame: Change from baseline to 12 week metabolic flexibility
Microbiome
Stool microbiome diversity
Time frame: Change from baseline to 12 week in the phyla, genus and species of gut bacteria
Short chain fatty acids
Stool Short chain fatty acids
Time frame: Change from baseline to 12 week short chain fatty acids, acetate, propionate, and butyrate (C4).
Vascular Health
Brachial and skin flow mediated dilation
Time frame: Change from baseline to 12 week vessel function
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