To compare efficacy and safety between bilateral superficial cervical plexus block combined with intravenous sedation (RA group) and general anesthesia (GA group) for thyroid and parathyroid operations. This study evaluates postoperative numerical pain score and systemic opioid requirement within 24 hours.
According to literature review, there is limit information about efficacy and safety of thyroid and parathyroid operations under bilateral superficial cervical plexus block combined with intravenous sedation without general anesthesia. General anesthesia is commonly used for neck operations because it is easy to perform. However in high cardiovascular or pulmonary risk patients such as end stage renal disease (ESRD) patients, regional anesthesia such as superficial cervical plexus block combined with intravenous sedation have become an alternative technique for neck operations. This study evaluate whether regional anesthesia (RA) technique can be the alternative technique for thyroid/parathyroid surgery compare to conventional technique (GA).
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
52
bilateral superficial cervical plexus
Dexmedetomidine 0.5 ug/kg infusion in 10 min then 0.5 ug/kg/h, Propofol infusion
local infiltration analgesia with 2%lidocaine with adrenaline 5 ug/ml 10 ml
Faculty of Medicine Siriraj Hospital, Mahidol University
Bangkok Noi, Bangkok, Thailand
RECRUITINGPostoperative pain score at rest
Numerical rating scale 0-10 (0=no pain, 10= worst pain imaginable)
Time frame: 0 hour at PACU ( time PACU arrival)
Postoperative pain score at rest
Numerical rating scale 0-10 (0=no pain, 10= worst pain imaginable)
Time frame: 1 hours at PACU
Postoperative pain score at rest
Numerical rating scale 0-10 (0=no pain, 10= worst pain imaginable)
Time frame: 6 hours at ward
Postoperative pain score at rest
Numerical rating scale 0-10 (0=no pain, 10= worst pain imaginable)
Time frame: 12 hours at ward
Postoperative pain score at rest
Numerical rating scale 0-10 (0=no pain, 10= worst pain imaginable)
Time frame: 18 hours at ward
Postoperative pain score at rest
Numerical rating scale 0-10 (0=no pain, 10= worst pain imaginable)
Time frame: 24 hours at ward
Postoperative pain score on swallow
Numerical rating scale 0-10 (0=no pain, 10= worst pain imaginable)
Time frame: 1 hour PACU
Postoperative pain score on swallow
Numerical rating scale 0-10 (0=no pain, 10= worst pain imaginable)
Time frame: average NRS at ward at 24 hours
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Induction with Propofol and intubation with cisatracurium
Postoperative morphine consumption
in milligram
Time frame: Cumulative dose within 24 hours
Complications
Percentage of patients present with hoarseness, dyspnea, local anaesthetic systemic toxicity
Time frame: within 24 hours
Patient's satisfaction scale score
satisfaction scale score 0-10 ( 0= highly unsatisfied, 10= highly satisfied)
Time frame: at 24 hours