Low-dose Aspirin for Prevention of Adverse Pregnancy Outcomes in Twin Pregnancies

Ministry of Science and Technology of the People´s Republic of China425 enrolled

Overview

Twin pregnancies are associated with increased risk of perinatal adverse outcomes , including preeclampsia , fetal growth restriction , preterm premature rupture of membranes and preterm birth. Low-dose aspirin was recommend by American College of Obstetricians and Gynecologists (ACOG) during pregnancy. In this trial, the investigators suppose that aspirin used in twin-pregnancies could improve adverse pregnancy outcomes.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

TRIPLE

Enrollment

425

Conditions

Twin Pregnancy Preeclampsia Preterm Birth Fetal Growth Restriction

Interventions

In LDA group, patients were asked for taking 100mg aspirin per night;

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 55 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Twin pregnancy diagnosed by ultrasound and maternal age ranged from 18 to 55 years, Gestational age was less than 16w Exclusion Criteria: * Diagnosed fetal anomalies, history of cervical cerclage, contraindications of aspirin, pre-existing renal or liver diseases or abnormal functions, coagulation disorders, history of PE, preterm birth or FGR, chronic hypertension

Locations (1)

Hongbo,Qi

Chongqing, Chongqing Municipality, China

RECRUITING

Outcomes

Primary Outcomes

The incidence of preeclampsia, preterm birth, fetal growth restriction

Time frame: after 30 weeks of gestional age

Data from ClinicalTrials.gov

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