Small studies suggest differences in efficacy and safety exist between olive oil-based and soybean oil-based parenteral nutrition regimens in hospitalized adult patients. A study in China suggested that olive oil-based parenteral nutrition provided effective nutrition, was well tolerated, was associated with fewer infections and conferred greater ease-of-use than soybean oil-based parenteral nutrition. The objectives of this study were to assess safety and efficacy of an ClinOleic-based lipid parenteral nutrition regimen compared with Structolipid-based lipid parenteral nutrition regimen in Chinese adults after pancreatectomy for whom oral or enteral nutrition was not possible, insufficient or contraindicated.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
200
ClinOleic group: Patients using ClinOleic or Structolipid-based lipid parenteral nutrition regimen. From day 0 to day 5, the goal of treatment is to deliver 25kcal/kg/day, 1.05g/kg/day amino acids, and 1.1g/kg/day lipid.
The First Affiliated Hospital of Nanjing Medical University
Nanjing, China
RECRUITINGbiomarkers of liver functions
Concentration of AST, ALT, TBIL, DBIL in the blood
Time frame: 48 hours after operation.
markers of infection and inflammation
Concentration of CRP, PCT in the blood
Time frame: 48 hours after operation.
Trenal function
Concentration of Crea, Urea in the blood
Time frame: 48 hours after operation.
lipids and lipid upper derivatives
Concentration of arachidonic acid, eicosapentaenoic acid, linoleic acid, oleic acid in the blood
Time frame: 48 hours after operation.
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