This study will evaluate the safety and tolerability of LY3475766 when given to participants with high levels of blood fat called triglycerides. It will also investigate how the body processes the study drug and the effect of the study drug on the body. Information about any side effects will be documented. This study will last up to 16 weeks for each participant.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
DOUBLE
Enrollment
48
WCCT Global
Cypress, California, United States
Covance Clinical Research Inc
Daytona Beach, Florida, United States
Covance Dallas
Dallas, Texas, United States
Covance Clinical Research Inc
Madison, Wisconsin, United States
Number of Participants with One or More Serious Adverse Event(s) (SAEs) Considered by the Investigator to be Related to Study Drug Administration
A summary of SAEs and other non-serious adverse events (AEs), regardless of causality, will be reported in the Reported Adverse Events module
Time frame: Baseline up to Day 85
Pharmacokinetics (PK): Area Under the Concentration Versus Time Curve (AUC) of LY3475766
PK: AUC of LY3475766
Time frame: Predose up to Day 85
PK: Maximum Observed Drug Concentration (Cmax) of LY3475766
PK: Cmax of LY3475766
Time frame: Predose up to Day 85
PK: Time to Maximum Observed Drug Concentration (Tmax) of LY3475766
PK: Tmax of LY3475766
Time frame: Predose up to Day 85
Pharmacodynamics (PD): Percent Change from Baseline in Triglycerides (TG)
PD: Percent Change from Baseline in TG
Time frame: Baseline, Day 85
PD: Percent Change from Baseline in Low-Density Lipoprotein Cholesterol (LDL-C)
PD: Percent Change from Baseline in LDL-C
Time frame: Baseline, Day 85
PD: Percent Change from Baseline in Apolipoprotein B (ApoB)
PD: Percent Change from Baseline in ApoB
Time frame: Baseline, Day 85
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Administered SC